GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs12216499 | 1 | rs12202783 | chr6:159388629 | RSPH3 | chr6:159398268-159421198:- | 0.22 | 4.01 | 6.55E-5 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12196860 | 1 | rs12203179 | chr6:55994237 | COL21A1 | chr6:55921389-56258892:- | 0.35 | 7.04 | 3.46E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12203286 | chr6:55994438 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.91 | 8.51E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12203407 | chr6:55994431 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.92 | 7.52E-12 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12203464 | chr6:55934339 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -6.94 | 6.82E-12 | Psychosis (atypical) |
| BRCA | cis | rs12216499 | 1 | rs12203483 | chr6:159386228 | RSPH3 | chr6:159398268-159421198:- | 0.21 | 3.79 | 0.000159 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12196860 | 1 | rs12203653 | chr6:55964693 | COL21A1 | chr6:55921389-56258892:- | -0.36 | -6.58 | 7.13E-11 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12204015 | chr6:86598334 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -19.55 | 5.73E-73 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs12204365 | chr6:86700532 | SNHG5 | chr6:86386726-86388451:- | -0.58 | -18.37 | 1.04E-65 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12204789 | chr6:55947818 | COL21A1 | chr6:55921389-56258892:- | -0.38 | -7.01 | 4.22E-12 | Psychosis (atypical) |
| BRCA | cis | rs2274459 | 1 | rs12204992 | chr6:33741724 | IP6K3 | chr6:33689443-33714762:- | 0.27 | 4.72 | 2.61E-6 | Obesity (extreme) |
| BRCA | cis | rs12196860 | 1 | rs12205230 | chr6:55995496 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.82 | 1.48E-11 | Psychosis (atypical) |
| BRCA | cis | rs1577917 | 1 | rs12205336 | chr6:86722367 | SNHG5 | chr6:86386726-86388451:- | -0.6 | -18.36 | 1.26E-65 | Response to antipsychotic treatment |
| BRCA | cis | rs12196860 | 1 | rs12205653 | chr6:55960169 | COL21A1 | chr6:55921389-56258892:- | -0.36 | -6.71 | 3.25E-11 | Psychosis (atypical) |
| BRCA | cis | rs12196860 | 1 | rs12205903 | chr6:55960583 | COL21A1 | chr6:55921389-56258892:- | -0.37 | -6.8 | 1.71E-11 | Psychosis (atypical) |